 Involves the MASSING OF A MIX OF DRY PARTICLES using a GRANULATING FLUID  OLDEST AND WIDELY USED METHOD which involves WET MASSING  The WET MASS IS FORCED THROUGH A SEIVE to PRODUCE GRANULES which are then dried  The granulating fluids usually used are volatile solvents (Ethanol, Isopropranol, and Water) (STATE THE ADV & DISADV)

Wet Granulation ADV: 1 Improves COHESIVENESS & COMPRESSIBILITY of powders with formulation of granules 2 SUITABLE for high dosage drugs with POOR FLOW or COMPRESSIBILITY 3 GOOD DISTRIBUTION and UNIFORM CONTENT for soluble low-dosage drugs 4 GOOD COLOR DISTRIBUTION 5 Ensures fixed composition of each granule during processing, transport, and handling 6 IMPROVES the DISSOLUTION RATE of HYDROPHOBIC DISADV: 1 Very costly 2 time and labor-consuming 3 NOT USEFUL for WATER and HEAT-SENSITIVE DRUGS