Factors affecting ADR: (Px-related factors) Pregnancy 1 causes JAUNDICE & BRAIN DAMAGE in the FETUS 2 BIRTH DEFECTS, and increased RISK OF BLEEDING problems in newborns and mothers 3 DEFECTS of the HEART (Ebstein’s Anomaly), lethargy, REDUCED MUSCLE TONE, and UNDERACTIVITY of the THYROID GLAND (Fetus)