PHARMCARE 3: Genetic Basis

1 FAULTY HYDROLYSIS: normal action of succinylcholine hydrolysis takes 5 MIN ,here it takes 1-2 HOURS, results in PROLONGED RESPIRATORY FAILURE

2 FAULTY OXIDATION, Phenytoin toxicity INCREASES in slow hydroxylators

Question

Genetic Basis

1 FAULTY HYDROLYSIS:  normal action of succinylcholine hydrolysis takes 5 MIN ,here it takes 1-2 HOURS, results in PROLONGED RESPIRATORY FAILURE

2 FAULTY OXIDATION, Phenytoin toxicity INCREASES in slow hydroxylators

LEIGHTON DWIGHT OBILLOS · Accepted Answer

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1 Atypical pseudocholinesterase

2 Hydroxylase polymorphism

Genetic Basis 1 FAULTY HYDROLYSIS: normal action of succinylcholine hydrolysis takes 5 MIN ,here it takes 1-2 HOURS, results in PROLONGED RESPIRATORY FAILURE 2 FAULTY OXIDATION, Phenytoin toxicity INCREASES in slow hydroxylators