Question:
What are examples of variations of enzymes in phase I?
Author: H KAnswer:
Most important ones are CYP2C, 2D and 3A, expressed in GI CYP3A5 affect CCB, cyclosporines... CYP2C8 affects retinoic acid CYP2C9 affects NSAIDs, phenytoin, warfarin CYP2C19 affects omepraazole, phenytoin, propranolol.
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Author
H K