What is the toxicity and side effects of anti-TB tx?

Isoniazid (ALT increase, hepatitis, neurotoxicity, hypersensitivity) Rifampin (pruritis, vomit, nausea, flu-like, hepatotoxicity, orange discoloration) Rifabutin (neutropenia, uveitis, polyarthralgia, hepatotoxicity) Rifapentine (same as rifampin) Pyrazinamide (hepatotoxicity, nausea, polyarthralgia, gouty arthritis, rash, photosensitive dermatitis) Ethambutol (retrobulbar neuritis 18%) So we should monitor and manage the doses according to side effects