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Endocrinology

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Question:

How is pathophysiology of metabolic syndrome leading to atherosclerotic CVD?

Author: H K



Answer:

Genetics and environmental causes lead to abdominal obesity, thus adipocytes release adipokines and cytokines lead to liver release of inflammatory markers, which cause insulin resistance and metabolic syndrome. Metabolic syndrome causes increase BP, TG and decrease HDL which lead to atherosclerosis, plaque rupture/thrombosis and cardiovascular event


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H K
H K