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Endocrinology

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Question:

Describe VLDL formation?

Author: H K



Answer:

Nascent VLDL w/high TG and ApoB100 are produced by liver, which receive ApoCII and ApoE from HDL to become VLDL, in capillaries bind LPL removes TGs, fatty acids to adipose and glycerol to liver, producing IDL, which lose ApoCII and ApoE to HDL and become LDL, bind to extrahepatic tissues and are endocytosed, go to liver and become nascent VLDL again.


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H K
H K