How is repair by cell proliferation?

By GF, depends on integrity of ECM, several type (remnant of injured tissue, vascular endothelial cells, and fibroblast proliferation) Determined by intrinsic proliferation capacity of tissues, some are labile can regenerate always proliferating (bone marrow stem cells, surface epithelia) and others are stable (G0 stage cells not proliferating only in case of injury like parenchyme (kidney liver pancreas/ endothelia, fibroblasts and smooth muscles) others are permenant (can't regenerate like neurons and cardiac muscle cells)