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Hematology

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Question:

How is heme biosynthesis by immature red cells?

Author: H K



Answer:

In mitochondria (glycine and succinyl CoA acted on by ALA synthase and vitamin B6 to form ALA, which will become protoporphyrin, which combines w/ iron from ferritin or transferrin coming from cytosol to become Heme) In cytosol (Globin chains are formed by translation, combines w/ heme to make hemoglobin tetramer)


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H K
H K