C. TISSUE REPAIR (Side Reactions to Tissue Injury) b) Altered Protein Synthesis: Acute- Phase Proteins 1 Cytokines released from macrophages and endothelial cells of injured tissues, __, act on cell surface receptors to INCREASE OR DECREASE TRANSCRIPTIONAL ACTIVITY of genes encoding certain proteins called POSITIVE & NEGATIVE ACUTE PHASE PROTEINS. 2 __ may play roles in minimizing tissue injury and facilitating repair. For example, many of them INHIBIT LYSOSOMAL PROTEASES released from the injured cells and recruited leukocytes.