What are the effects of alcohol?

Most are metablized by ADH/ cytochrome p450/ catalase to acetaldehyde. Acute alcoholism (effect CNS, hepatic and gastric injury possible, fat droplets may accumulate in cytoplasm of hepatocytes (steatosis)) Chronic alcoholism (massive bleed from gastritis, gastric ulcers, esophageal varices, cirrhosis associated) Alcoholic hepatitis (steatosis, inflammation and ballooning degeneration hepatocellular injury. Cellular swelling of hepatocytes w/clumped IF called Mallory body. fibrosis not diagnostic, as disease progresses we see cirrhosis, mallory bodies persist several months after cessation of drinking and associated w/risk for cirrhosis) CV effects (dilated congestive cardiomyopathy) Fetus (fetal alcohol syndrome (microcephaly, retard) Carcinogenesis (oral, esophageal, liver) Pancreatitis (acute/chronic) Malnutrition (ethanol consumed more than food lead to Vitamin B deficiencies)