What are factors influencing tissue necrosis extent?

➢ The duration of circulatory interruption ➢ Sensitivity of the tissue and cell to anoxia.The higher the oxidative metabolism, the more vulnerable they are; ́Nervous tissue is the most sensitive. ➢ The type of terminal circulatory system makes the tissue more vulnerable than the anastomotic system; The presence of innate or acquired anastomotic replacements of the circulatory system, or a dual-circulation device (lung) provide relative protection to the tissue.