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TOXICOLOGY

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Question:

(DECREASE IN TOXIN LEVEL) → chelating agent. They act by binding in toxic chelation by structure of sulfhydryl group. combined with heavy metals will form a relatively non- stable, non-toxic chelate that is easily excreted in urine. DECREASES EFFECT IF URINE IS ACIDIC or the patient is acidic. → More effective, soon after exposure with gold induce thrombocytopenia, symptomatic or asymptomatic mercury poisoning with mercury whole blood

Author: LEIGHTON DWIGHT OBILLOS



Answer:

Dimercaprol → Combination with EDTA, you should give first Dimercaprol before EDTA to prevent the distribution of the lead to the brain. Disadvantage - if metal itself is metabolize to liver, dimercaprol is not effective. It is also short half life and readily excreted to urine.


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