→ causes sinking of lipid by expanding the lipid compartment within the intravascular space therefore, sequestering the lipid soluble drug from tissue. → Intralipid efficacy is Related to metabolic effect in myocardium, specifically, ability to enhance fatty acid intracellular transport in myocardial cells → Used for treatment of poisoning by lipid poisoning drugs like Bupivacaine, propranolol, verapamil.