How is pathogenesis of sarcoidosis?

Epithelioid non-caseating granuloma formation, any tissue could be affected, Th1 CD4+ T cells, macrophages express cytokines and TNF, granuloma can either resolve w/out sequelae, or undergo obliterative fibrosis with interstitial firbosis. Granuloma is formed of border of CD8+ T cells, monocytes, mast cells, fibroblasts, and center of macrophage, epithelioid cells, Multinucleated giant cells and CD4+ T cells