How is pathogenesis and risk factors for BCP crystal diseases?

Not fully understood, occur in sites of injury, produce symptoms and mediate tissue damage by several mechanisms including induction of inflammation, biochemical disruption, interaction with CT, producing cytokines in absence of inflammation. Risk factors include (severe radio damage in OA, CPP crystals, hx of trauma/heavy use [Milwaukee shoulder syndrome], ESRD, CT disease, genetic) Average age is 72 years.