How are criteria of dx for SLE?

We have clinical and immunologic criteria, required >4 or biopsy ANAs (seen by immunofluorescence, low specificity, in healthy/low titer individuals) Ab to extractable nuclear Ag (anti-dsDNA [LN end stage renal disease increased severity and poor survival], APS [venous, CNS, death], anti-Ro/La [neonatal lupus, congentical heart block, seropositive mothers and children)