What are clinical manifestations of ASD?

Fever (96%, sudden onset spiking high fever, peak once daily late afternoon/early evening, exceeds 39 degrees, lasts under 4 hours, returns normal 80% of time without antipyretic) Rash (73%, evanescent, salmon-pink, macular/maculopapular, proximal limbs and trunk, emerges with fever in evening, koebner/mild pruritis) Musculoskeletal (arthritis 64-100%, may be mild, oligoarticular, transient, evolves over several months to more severe destructive symmetrical and polyarticular form, knees, wrist and ankles, elbows..., progressive changes in wrist 6 months after onset, develop ankylosis 1.5-3 years later, myalgia and myositis) Sore throat (69%, typical sign, common in 1st month subsequent flares) Liver disease (50-70%, hepatomegaly and LFT abnormal, fatal fulminant) Lymphadenopathy and Splenomegaly (50%, tednerness, biopsty polyclonal B cells hyperplasia) Cardiopulmonary disease (30-40%, pleuritis, pericarditis, ARDS, Tamponade) Hemato (pancytopenia due to hematophagic syndrome)