How is M&M of FMF?

Nephrotic syndrome (before intiuition of cholchicine therapy mortality due to it was atmost at age 50 years. Appendectomies (severe peritoneal episodes seemed to indicate appendicitis which caused pt to get appendectomy) Chronic arthritis (5% of pt sometimes lead to destructive arthritis of hips/knees and may necissate joint replacement) 10% pt with chronic arthritis develop seronegative SpA. Fertility and pregnancy (1/3 females are infertile, 20-30% get fetal loss pregnancy)