How is storage of NE in vesicles?

Dopamine then is transported to vesicles by amine transporter involved also in reuptake of NE, this carrier system is blocked by reserpine, dopamine then is hydroxylated to form NE by enzyme dopamine beta-hydroxylase. Then NE is methylated to make Epi both of which are stored in chromaffin cells of adrenal medulla, with stimulation medulla releases 80% Epi and 20% NE into circulation