What is the genetic basis of suicide and mental illness?

We have in our genes the instinct of survival, but w/some diseases we get to suicide Ernest Hemingway (nobel prize, suicide, 5 suicides in family) Charolette Salomon (6 suicides in 4 gens) Van Gogh (was bipolar and shot himself) Elevated expression of Glutamate receptors in NE neurons from locus coeruleus in MDD is seen (higher NMDA receptor subunits, GRIN2B and GRIN2C and metabotropic receptor genes GRM4 and GRM5 all in locus coeruleus. Antagonists of Glut receptors reduce depressive symptoms faster than antidepressants, as glut is a prominent excitatory input to the NA LC so LC becomes overactive in MDD.