What is DIC?

• Sepsis, especially E.coli and Neisseria meningitis • Malignancy- any cancer especially APL (promyrlocytic leukemia) M3 • Obstetrical complications (eg eclampsia) • Trauma- especially crush injury and burns • Snake bites • Activation of coagulation system • Leading to extensive thrombus formation in the microvaculature resulting in: • Obstruction of flow → tissue hypoxia • Consumption of clotting factors and plt → risk of bleeding • Activation of the fibrinolytic system → production of FDP/D-dimer