What is PF?

Proliferation of abnormal clone of hematopoietic stem cell in bone marrow and other sites results in fibrosis. Myelofibrosis is a form of myeloid metaplasia, which refers to a change in cell type in the blood forming tissue of bone marrow, progressive scarring or fibrosis of bone marrow occurs, results in extramedullary hematopoiesis. Anemia, with enlarged spleen the blood film with leukoerythroblast and RBC w/tear drop.