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Hematology

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Question:

What is NHL Burkitt lymphoma?

Author: H K



Answer:

Endemic and sporadic forms w/EBV infection, most carry translocations involving C-myc gene on chrmsm 8, most of these is t(8;14) putting C-myc gene with heavy chain gene, leads to unregulated overexpression of C-myc promoting cell growth and division. Diffuse infiltrates of medium sized cells, large numbers of mitotic and apoptotic cells, scattered benign macrophages (Starry sky)


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H K
H K