Describe and specify pathologies of serum protein electrophoresis?

A 1 zone (orosomucoid and antitrypsin, but mostly antitrypsin. decreased band in nephrotic syndrome, and AAT deficiency, leads to emphysema from unregulated lung elastase breakdown by neutrophils in lung tissue, AAT increased in positive acute phase reactant acute inflammation, bound by Bence Jones protein) a2 zone (principally of a2 macroglobulin AMG and haptoglobin, typically low levels of hemolytic anemia, raised in acute phase response during inflammation)