How is onset, symptoms and pathophysiology of transfusion associated GVHD?

Onset: TA-GVHD typically manifests within 1 to 6 weeks after transfusion, with symptoms becoming apparent around 7 to 14 days post-transfusion. Symptoms: TA-GVHD presents with symptoms similar to classical GVHD, including skin rash, diarrhea, fever, liver dysfunction, and bone marrow suppression. Pathophysiology: TA-GVHD occurs when viable T lymphocytes present in the transfused blood recognize the recipient's tissues as foreign and mount an immune response, leading to tissue damage. Unlike classical GVHD, which primarily occurs after allogeneic hematopoietic stem cell transplantation, TA-GVHD involves immunocompetent donor T cells attacking host tissues in immunocompromised recipients