What are contraindications for HSCT (hematopoietic stem cell transplant)?

Active infection/inflammation Non-recovery of counts pre-HCT (prolonged neutropenia) Non-remission MRD positivity Underlying organ damage Pulmonary (FEV1, DLCOc <50%), Hepatic (LFTs >5x ULN, T bil >2), Cardiac (EF <50%), Renal (GFR < 70)—all risks Performance Status (low KS/LPS) <90 falls off, <60 major decline Psychiatric Disorder requiring significant therapy Some of these issues can be addressed with reduced intensity regimen approaches