How do doses of stem cells vary by source?

Autologous: Target >2x106 CD34 cells/kg recipient wt Allogenic: Bone marrow, PBSC matched related and unrelated donors Target >4-5x106 CD34 cells/kg recipient wt Can go higher, debate about upper limit re GVHD concerns T-cell depleted/haploidentical Target >10-20x106 CD34+ cells/kg recipient wt Target <1x105 CD3+ cells/kg recipient wt Cord Blood Target >4x107 TNC/kg single unit For highly mismatched >5x107/kg recipient wt Multiple units as needed for at least 3x107/kg recipient wt No advantage to 2 units if single unit dose adequate, more GVHD with 2 units