What are veno-occlusive diseases (Sinosoidal obstruction syndrome SOS)?

Typically in first 14 days of transplant, up through day +30 About 25% patients affected, severe in 5-8% Caused by endothelial damage in the hepatic venules → platelet deposition → hepatic congestion → cholestasis Associated with Cy, Busulfan, and TBI New data show sirolimus use is a risk when used with tacrolimus or cyclosporine