What are effects of long-term cannabis use?

Medical, Gateway effects Neurotoxic effects (deficits in cognitive function memory and attention, education and occupational. Mechanism: THC induce cell death, decreased cerebral blood flow) Mental health (gateway drug, amotivational syndrome, psychosis/schizophrenia [psychosis among vulnerable, exacerbates symptoms and prolongs illness, helps self medicate psychiatric symptoms or medication side effects] Depression and anxiety increases + suicide attempts)