How is opioid withdrawal?

A. Either of the following: (1) Cessation of (or reduction in) opioid use that has been heavy and prolonged (several weeks or longer) (2) Administration of an opioid antagonist after a period of opioid use. B. Three (or more) of the following, developing within minutes to several days after Criterion A: (1) Dysphoric mood (2) Nausea or vomiting (3) Muscle aches (4) Lacrimation or rhinorrhea (5) Pupillary dilation, piloerection, or sweating (6) Diarrhea (7) Yawning (8) Fever (9) Insomnia