Question:
How is dompamine hypothesis?
Author: H KAnswer:
Amphetamine (very high doses) ? paranoia, delusions, auditory hallucination, also exacerbates symptoms of schizophrenia. Effects blocked by DA antagonist chlorpromazine Phenothiazines & all other typical neuroleptics block D2 receptors and alleviate (+) symptoms. Can be seen by 5 dopamine pathways (nigrostriatal [control motor function, parkinsonism, tremor, rigidity], mesolimbic [pleasure sensation, euphoria of drugs, delusions], mesocortical [cognitive symptoms and affective symptoms negative symptoms], tuberoinfundibular [ant pituitary and PRL, normal in schizo], multiple site pathway unknown)
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