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Pharmacology

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Question:

How is mechanism of action of organic nitrates?

Author: H K



Answer:

Simple nitric and nitrous esters of glycerol, NO activates guanylyl cyclase, increases cGMP, dephosphorylates myosin causing relaxation of smooth muscles, so rapid decrease in O2 demand leading to rapid resolution of symptoms of angina.


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Author

H K
H K