Question:
What is mechanism of action of class IA agents?
Author: H KAnswer:
Quinidine binds to open and inactivate Na+ channels prevent Na+ influx in phase 0, slows the rate of depolarization and conduction, prolong repolarization by blocking some K+ channels, increase ventricular effective refractory period ERP, slows conduction Other actions (mild a antagonist and anticholinergic)
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