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Pharmacology

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Question:

What is mechanism of action of class IA agents?

Author: H K



Answer:

Quinidine binds to open and inactivate Na+ channels prevent Na+ influx in phase 0, slows the rate of depolarization and conduction, prolong repolarization by blocking some K+ channels, increase ventricular effective refractory period ERP, slows conduction Other actions (mild a antagonist and anticholinergic)


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Author

H K
H K