How are pharmacokinetics of statins?

Oral absorption is variable and High plasma protein binding Metabolism: Atorvastatin, Lovastatin and simvastatin are primarily metabolized by CYP3A4 Pravastatin and Rosuvastatin: insignificantly metabolized by CYP Plasma half life: Atorvastatin (14 h) and Rosuvastatin (19h) have long t1/2, the others 1-2 h