Question:
How is tx and prognosis of T1 low grade urothelial cancer?
Author: H KAnswer:
The treatment is usually bladder instillation with chemotherapy agents which the most common is mitomycin (mixed with normal saline and then infused in the bladder) to reduce the progression (local treatment, no needle). we already did urine cytology, if it’s high grade: 90% it’s positive because the test is very sensitive. If the urine cytology is negative, and we found a tumor in surgery, we perform a resection and we give him mitomycin or clindamycin right after surgery Follow up for T1 low grade: 3 times cystoscopy every for 3 years, then twice the 4th year, then once the 5th year to check for recurrence, if all are negative, our patient has become cancer free. T1 low grade: 60% risk of progression (become T2) and 85% of recurrence. With treatment, recurrence becomes 40% and progression 20%.
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