How are the genetics of exocrine ca?

K-ras mutation Found mutation in 90% of Pt with CA pancreas w/o in DNA from serum ,stool , Pancreatic Juice , Pancreatic tissue HER-2/neu oncogene EGFr , overexpression in CA Pancreas Tumor-suppressor genes P53 , p16 & DPC4 (Smad4) , BRCA2 Multiple mutations in above genes Gene related to expression of GF and GFr