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Dermatology

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Question:

What are labs of pemphigoid gestationis?

Author: H K



Answer:

• Histologic findings of a subepidermal blistering process and DIF: linear band of C3 deposition with or without Ig G (present in 20-25% of patients) along the basement membrane • The DIF test is the key assay to differentiate pemphigoid gestationis (positive DIF findings) from pruritic urticarial papules and plaques of pregnancy (negative DIF findings) • IDIF: for the detection of autoantibodies to BP180 antigen in patients with pemphigoid gestationis and that enzymelinked immunosorbent assay is useful to monitor autoantibody serum levels • HLA-DR3/DR4 is present in 45% of patients with pemphigoid gestationis, as compared with 3% of the general population


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H K
H K