How is urine cytology in UC?

• Voided urine: Non invasive, easiest to obtain Obtaining 3 second morning voided midstream urine samples collected over 3 consecutive days appears to optimize the detection of urothelial malignancies • Instrumented urine: Catheterization of the bladder or irrigation of bladder Paris system for reporting of urinary cytology, Enlarged nuclei with high N/C ratio (> 0.7), hyperchromasia, clumped chromatin