How is humoral response histology?

• B-cells are activated by foreign proteins (antigens) and differentiate into plasma cells • Plasma cells make immunoglobulin • IgG: monomer, lots of it in plasma, neutralizes antigens • IgM: pentamer, initial immune response, high levels in acute infection • IgA: dimer, present in secretions (saliva, breast milk, tears), protects mucosal surfaces • IgE: monomer, allergic and antiparasite responses • IgD: monomer, small amount in plasma, triggers initial B-cell activation