How is small lymphocytic lymphoma?

• Low grade B-cell malignancy, = chronic lymphocytic leukemia (CLL), Frequency ~ 4% of NHL, Most common leukemia of adults, Older age group (median, 60.5 years), Bone marrow involvement: Common, Indolent course • Often asymptomatic at diagnosis • Nonspecific –fatigue, weight loss, anorexia • Generalized lymphadenopathy • Hepatosplenomegaly • Disrupts normal immune function through uncertain mechanisms (hypogammaglobinemia, autoantibodes -> anemia, thrombocytopenia) • Variable course and prognosis • Tendency to transform to more aggressive tumors – Prolymphocytic and large-cell transformations (latter = Richter syndrome) – poor prognosis • Diffuse effacement of parenchyma by small, mature lymphocytes • Round nucleus, clumped chromatin with only small nucleoli and scant cytoplasm Proliferation centers pathognomic, immuno CD20, CD5, CD23