What is indication for splenectomy?

• Diagnostic splenectomy when neither PB examination nor BM assessment highlights the presence of a lymphoid neoplastic clone. • Patients receiving a generic diagnosis of B-cell chronic lymphoproliferative disorder after PB and BM assessment: Avoid splenectomy as a mere diagnostic refinement. • Given the indolent pace of the SLs commonly falling in this “basket diagnosis,” (SMZL, SL-u, and LPL), allowing the adoption of a watchful waiting policy, we consider splenectomy only when it fully matches the need of a therapeutic intervention.