What is littoral cell angioma?

• Rare tumor • Arises from littoral cells: These cells have features intermediate between those of endothelial cells and macrophages. • Anastomosing vascular channels which may anastomose with normal splenic sinuses at the periphery. The vascular channels may have a pseudopapillary aspect • The vascular spaces are lined by tall plump cells which express both endothelial and histiocytic markers. • IHC: CD68+, CD31+, ERG +