How are clinical features of squamous cell carcinoma?

➢ Invasive squamous cell carcinomas of the skin often are discovered while small and resectable (<1% will have metastatic lymph nodes at diagnosis). ➢ The metastasis risk is related to the thickness of the lesion and degree of invasion into the subcutis. ➢ Tumors arising from actinic keratoses may be locally aggressive but generally metastasize only after long periods of time ➢ Those arising in burn scars, ulcers, and non–sun-expose skin often behave more aggressively. ➢ Squamous cell carcinomas arising at internal sites are generally invasive and aggressive, possibly because (unlike in the skin) early lesions go unrecognized.