How is classification of cervical precursor lesions?

➢ SIL is divided into low-grade squamous intraepithelial lesion (LSIL/CIN I, and high-grade squamous intraepithelial lesion (HSIL /CIN II and III. ➢ LSIL is associated with productive HPV infection and does not progress directly to invasive carcinoma. ➢ Most LSILs regress and only a small percentage progress to HSIL. ➢ HSIL demonstrates increased proliferation, arrested epithelial maturation, and lower levels of viral replication. ➢ LSIL is not treated as a premalignant lesion, whereas HSIL is considered at high risk for progression to carcinoma. ➢ LSIL is 10 times more common than HSIL ➢ While HSILs are precancerous, the majority of them fail to progress to cancer and may even regress