How is incidence of surface epithelial tumors?

➢ Important risk factors for ovarian cancer include nulliparity, family history, and germline mutations in certain tumor suppressor genes. ➢ There is a higher incidence of carcinoma in unmarried women and married women with low parity. ➢ Of interest, prolonged use of oral contraceptives reduces the risk. ➢ Around 5% to 10% of ovarian cancers are familial (most associated with mutations in the BRCA1 or BRCA2 tumor suppressor genes). ➢ The average lifetime risk for ovarian cancer is approximately 30% in BRCA1 carriers; the risk in BRCA2 carriers is somewhat lower. ➢ BRCA1 and BRCA2 mutations are found in only 8% to 10% of sporadic ovarian cancers.