How is gallbladder carcinoma?

DEFINITION Malignant neoplasm of the gallbladder, the majority of which are adenocarcinomas. INCIDENCE Extremely rare (< 1% of patients with cholelithiasis); incidence increases with age with a peak at 75 years; female:male ratio 3:1 RISK FACTORS Include porcelain gallbladder, gallstones, choledochal cysts, gallbladder polyps, and typhoid carriers with chronic inflammation. SIGNS AND SYMPTOMS Most patients are asymptomatic until late in the course when findings may include abdominal pain, nausea, vomiting, weight loss, RUQ mass, hepatomegaly, or jaundice.