What are morphology of focal segmental glomerulosclerosis?

➢ Increased mesangial matrix ➢ obliterated capillary lumina ➢ Deposition of hyaline (hyalinosis) and foamy (lipid-laden) macrophages. ➢ In affected glomeruli, IF microscopy often reveals nonspecific trapping of immunoglobulins, usually IgM, and C3 in the areas of hyalinosis. On EM, the podocytes exhibit effacement of foot processes, as in minimal-change disease. ➢ A morphologic variant : collapsing glomerulopathy is characterized by collapse of the glomerular tuft and epithelialcell hyperplasia. This more severe variant may be idiopathic or may be associated with HIV infection, drug-induced toxicities, and some microvascular injuries. It carries a particularly poor prognosis