What is C3 glomerulopathy?

➢C3 glomerulopathy encompasses two conditions, dense deposit disease (formerly MPGN, type II) and C3 glomerulonephritis. ➢These are relatively rare diseases with certain shared clinical, morphologic, and pathogenic features that may be part of a spectrum of injury. ➢They are set apart by differences in the electron microscopic appearance. ➢Patients may present with nephrotic or nephritic syndrome, ➢however, cases with only mild proteinuria also occur. ➢Patients with dense deposit disease are usually younger and more likely to have low serum C3 levels than patients with C3 GN, although these distinctions are subtle