What are clinical features of RPGN?

➢ The onset of RPGN is much like that of the nephritic syndrome, except that the oliguria and azotemia are more pronounced. ➢ Proteinuria sometimes approaching the nephrotic range may occur. ➢ Some affected individuals become anuric and require long-term dialysis or transplantation. ➢The prognosis is roughly predicted by the fraction of involved glomeruli : Patients in whom crescents are present in less than 80% of the glomeruli have a more favorable prognosis than those in whom the percentage of crescents is higher. ➢Plasma exchange may be of benefit in those with anti-GBM antibody GN and in some cases of ANCA-related pauci- immune crescentic GN